formulation of a traditionally used polyherbal product for burn healing and hptlc fingerprinting of its phenolic contents

نویسندگان

shirin fahimi traditional medicine and materia medica research center and department of traditional pharmacy, school of traditional medicine, shahid beheshti university of medical sciences, tehran, iran

seyed alireza mortazavi department of pharmaceutics, school of pharmacy, shahid beheshti university of medical sciences, tehran, iran

mohammad abdollahi department of pharmacology and toxicology, faculty of pharmacy and pharmaceutical sciences research center, tehran university of medical sciences, tehran, iran

homa hajimehdipoor traditional medicine and materia medica research center and department of traditional pharmacy, school of traditional medicine, shahid beheshti university of medical sciences, tehran, iran

چکیده

nowadays, plants have been considered as powerful agents for treatment of disorders regarding to their traditional use. in iranian traditional medicine (itm), plants have a special role in the treatment of various diseases. burns with their devastating outcomes have been discussed in itm as well. in the present study, a polyherbal ointment (pho), retrieved from itm, was formulated for burn healing and it’s hptlc fingerprint was prepared. aqueous extracts of malva sylvestris and solanum nigrum leaves and oily extract of rosa damascena petals (4.85%, 4.85% and 33%, respectively) were added to white beeswax, eucerin and white petrolatum as ointment base. in addition to the microbiological tests, physical stability and rheological behavior of the product were assessed. fingerprinting of phytochemical constituents of pho was performed by using silica gel plates and toluene: ethyl acetate: acetic acid (60: 40: 1) and ethyl acetate: formic acid: acetic acid: water (100: 11: 11: 10) as mobile phases. the results showed that pho was stable towards physical changes and successfully passed microbiological tests. moreover, pho exhibited plastic behavior which is in favor of a topical burn product. in addition, hptlc fingerprinting of pho demonstrated the presence of several phenolic constituents corresponding to the plant extracts. regarding to the role of phenolic compounds in wound healing process, pho could be an appropriate candidate for burn healing with respect to its traditional use in itm. moreover, hptlc fingerprinting could be utilized as an applicable method for quality control of the prepared formulation.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Formulation of a Traditionally Used Polyherbal Product for Burn Healing and HPTLC Fingerprinting of Its Phenolic Contents

Nowadays, plants have been considered as powerful agents for treatment of disorders regarding to their traditional use. In Iranian Traditional Medicine (ITM), plants have a special role in the treatment of various diseases. Burns with their devastating outcomes have been discussed in ITM as well. In the present study, a polyherbal ointment (PHO), retrieved from ITM, was formulated for burn heal...

متن کامل

Formulation of a Traditionally Used Polyherbal Product for Burn Healing and HPTLC Fingerprinting of Its Phenolic Contents

Nowadays, plants have been considered as powerful agents for treatment of disorders regarding to their traditional use. In Iranian Traditional Medicine (ITM), plants have a special role in the treatment of various diseases. Burns with their devastating outcomes have been discussed in ITM as well. In the present study, a polyherbal ointment (PHO), retrieved from ITM, was formulated for burn heal...

متن کامل

Formulation of a Traditionally Used Polyherbal Product for Burn Healing and HPTLC Fingerprinting of Its Phenolic Contents

Nowadays, plants have been considered as powerful agents for treatment of disorders regarding to their traditional use. In Iranian Traditional Medicine (ITM), plants have a special role in the treatment of various diseases. Burns with their devastating outcomes have been discussed in ITM as well. In the present study, a polyherbal ointment (PHO), retrieved from ITM, was formulated for burn heal...

متن کامل

Formulation of a Traditional Polyherbal Product to a Standard Pharmaceutical Syrup and Development of Its Quality Control Methods

Background and objectives: People interest in traditional medicine has increased recently; however, traditional herbal medicines should be transformed into modern forms of medicine to increase patient acceptance. In this investigation, a polyherbal traditional combination “Monzej-e-balgham” has been based on according to Iranian traditional medicine (ITM) manuscripts and its qu...

متن کامل

wound healing activity of a traditionally used poly herbal product in a burn wound model in rats

conclusions poly herbal cream experimentally and histopathologically revealed a burn wound healing activity probably due to the antioxidant, anti-inflammatory and antimicrobial activities of its phytochemical contents. therefore, this study confirms the use of m. sylvestris, s. nigrum and r. damascena in burn prescriptions in itm. results there was a significant improvement in healing percentag...

متن کامل

A Wound Healing Formulation Based on Iranian Traditional Medicine and Its HPTLC Fingerprint

The present study reports formulation of a traditionally used poly herbal product for wound healing and its chromatographic analysis by HPTLC. Herbal therapy was the common treatment prescribed by Iranian physicians for wound healing. “Zemad”, the most ancient pharmaceutical dosage form used in the Iranian Traditional Medicine (ITM) for skin diseases. In this study, a poly herbal paste (PHP) wi...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of pharmaceutical research

جلد ۱۵، شماره ۱، صفحات ۹۵-۱۰۵

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023